遗传易感性和空气污染对心血管疾病的协同效应

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Yun-Jiu Cheng¹, Li-Juan Liu^2,3, Su-Hua Wu^2,3

¹Department of Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

American journal of preventive cardiology

|January 9, 2026

概括

遗传易感性和空气污染显著增加心血管疾病 (CVD) 的风险. 它们的综合作用是协同作用的,高遗传风险和污染暴露构成最大的危险.

科学领域:

环境健康环境健康
遗传学遗传学是一个
心血管疾病流行病学

背景情况:

心血管疾病 (CVD) 的确定的风险因素包括遗传易感性和空气污染.
关于遗传风险与空气污染之间的相互作用的证据有限,特别是在附加规模上.

研究的目的:

调查长期空气污染物暴露和多基因风险对发生心脏病的单独和联合影响.
在一个大群体中评估遗传风险得分和空气污染水平之间的相互作用.

主要方法:

利用考克斯模型估计与PM2.5,PM10,NO2和NOx相关的心血管疾病的危险比率,在未来的英国生物银行队列中 (460,572名参与者).
构建了对心血管疾病的多基因风险评分 (PRS),并评估了PRS和空气污染暴露之间的附加和乘法相互作用.

主要成果:

在11.92年的时间里,记录了48,690例心血管疾病病例.
较高的遗传风险和增加的空气污染暴露量独立地与心血管疾病风险增加有关.
观察到一个显著的协同效应:具有高遗传风险和高污染暴露的个体具有最大的危险 (例如,PM2.5的HR为1.76).

结论:

研究结果表明,在增加心血管疾病风险方面,遗传倾向和空气污染之间存在协同作用.
结果支持重新评估空气质量标准,并突出了基因分析的潜力,以确定有助于减轻污染的高效益亚群.

关键词:

空气污染大气污染心血管疾病是什么心血管疾病遗传易感性遗传易感性多基因风险评分多基因风险评分.

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