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美国风湿性关节炎死亡率的趋势,1999-2020年
Aamir Shahzad1, Haji Bahar Ali2, Muhammad Bilal3
1Department of Trauma and Orthopedic Surgery, Tameside and Glossop Integrated Care NHS Foundation Trust, Greater Manchester OL6 9RW, United Kingdom.
Journal of orthopaedic case reports
|January 9, 2026
概括
风湿性关节炎 (RA) 死亡率在2019年之前显著下降,但在2020年急剧增加. 在种族/民族群体和农村人口中,RA死亡率的差异仍然存在.
科学领域:
- 类风湿病学 类风湿病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性疾病,与全身并发症和死亡率增加有关.
- 预计RA治疗的进步将降低相关死亡率.
研究的目的:
- 分析1999年至2020年美国类风湿性关节炎 (RA) 相关死亡率的国家趋势.
- 评估RA死亡率的变化和差异,按性别,年龄,种族/族裔,地区和城市化情况进行评估.
主要方法:
- 作为潜在原因的RA,WONDER多重死亡原因数据库的回顾性分析 (ICD-10代码M05.x,M06.x,M08.0).
- 计算了年龄调整的死亡率 (AAMR),并使用结点回归来评估趋势和年度百分比变化 (APC).
- 根据人口和地理因素进行分层分析.
主要成果:
- 从1999年到2019年,RA死亡率每年下降约-2%至-3%,但在2020年急剧上升.
- 观察到显著的差异:女性的死亡率较高,美洲印第安人/阿拉斯加原住民和农村人口的持续高率.
- 2020年死亡率有所反弹,特别是在黑人和西班牙裔人口以及非大都市地区.
结论:
- 虽然RA死亡率在2019年之前总体下降,但收益分布不均,持续存在差异.
- 2020年RA死亡率的惊人上升可能与COVID-19大流行有关.
- 解决RA结果的近期增加和持续的人口差距需要持续的研究和有针对性的干预措施.
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