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Updated: Jul 1, 2026

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时间多组织分析揭示了与免疫反应和疟疾寄生虫控制相关的代谢物

Awet Alem Teklemichael1, Jian Wu1, Eric Bohrnsen2

  • 1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

iScience
|January 9, 2026
PubMed
概括

疟疾感染改变了宿主的新陈代谢. 补充尿素,一个关键的代谢物,显著降低了寄生虫水平和炎症,提供了潜在的新疟疾治疗策略.

关键词:
免疫学 免疫学 免疫学微生物学 微生物学

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Malaria01:29

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...