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连续D-二次体测量可以动态预测急性胆道胰腺炎的疾病严重程度:一项前性观察性研究

Kemal Tekeşin¹, Tolga Canbak¹, Aylin Acar¹

¹Department of General Surgery, University of Health Sciences, Ümraniye Training and Research Hospital, İstanbul, Turkiye.

Turkish journal of medical sciences

|January 9, 2026

概括

与传统的评分系统相比,连续的D-二次体测量,特别是在48小时后,可以更好地预测中度至严重的急性胆道胰腺炎. 这种可访问的生物标志物有助于早期风险分层.

科学领域:

胃肠病学胃肠病学
血液学血液学血液学
临床诊断临床诊断临床诊断

背景情况:

急性胆道胰腺炎 (ABP) 需要早期风险分层来有效管理.
像兰森标准这样的传统评分系统可能很复杂,会延迟治疗.
炎症和凝血的标志物D-二聚体显示出预后潜力.

研究的目的:

调查是否连续血清D-二聚体测量可以比兰森和BISAP得分更准确地预测中度至严重的急性胆炎.
评估D-二聚体作为可访问的生物标志物在ABP中早期风险评估的实用性.

主要方法:

一个单一中心前性观察性研究包括264名患有ABP的患者.
根据重度 (轻度,中度,重度) 患者被分类,使用修订的亚特兰大分类.
血清D-二聚合物水平在入院时 (H0),24小时 (H24) 和48小时 (H48) 测量;BISAP分数也被记录用于比较.

主要成果:

在所有时间点 (p < 0.001) 中,平均D-二聚合物水平与ABP严重程度有显著的相关性.
在H48的D-二元体显示了中度至重度ABP (AUC:0.812) 的最高预测准确性,超过了兰森 (H48 AUC:0.741) 和BISAP (H24 AUC:0.755) 的得分.
在H24和H0的D-二元水平也显示出良好的预测值 (AUC分别为0.728和0.719).

结论:

血清D-二聚物水平与ABP严重程度密切相关,并作为一个实用,具有成本效益的辅助生物标志物.
连续测量D-二次体,特别是在48小时后,比单独的Ranson和BISAP得分提供更高的诊断准确性.
在48小时内对D-二聚体进行临床测量,为ABP风险评估提供了及时和可访问的分拣方法,需要进一步的多中心验证.

关键词:

在急性胰腺炎中,在BISAP中获得的分数.D-二聚子 D-二聚子兰森的标准是什么生物标志物生物标志物疾病的严重程度.

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