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兰化物复合物与以乙芬为基础的推拉天线作为高效的MRI和两光子显微镜成像探针

Baptiste Chartier^1,2, Luke Marchetti³, Lamiaa M A Ali⁴

¹Univ. Grenoble Alpes, CNRS, CEA, IRIG, LCBM (UMR 5249) F-38000 Grenoble France olivier.seneque@univ-grenoble-alpes.fr.

Chemical science

|January 9, 2026

概括

研究人员开发了用于多式成像的新型兰坦化物复合物. 一种新的DOTA类型联体使得稳定的加多 (Gd³⁺) MRI对比剂和欧 (Eu³⁺) 光学探针具有出色的水溶性和准能力.

科学领域:

协调化学协调化学
生物医学成像技术生物医学成像技术
材料科学材料科学材料科学

背景情况:

兰化物 (Ln³⁺) 复合物为多式成像探头提供独特的磁性和光学性能.
开发符合MRI和光学探针要求的单个连接体是具有挑战性的.

研究的目的:

设计和合成一种新的DOTA型联体,用于创建稳定,多式联体的兰坦化物复合物.
评估这些复杂物作为MRI对比剂和光学成像探针的潜力.

主要方法:

一个DOTA类型的配体与 π 扩展的乙芬部分的合成.
兰化物 (Ln³⁺) 复合物的形成和表征.
评估动力惰性和热力学稳定性的评估.
评估Gd³⁺复合体的*in vivo*MRI对比特性.
使用一光子和两光子 (2P) 激发,评估Eu³⁺复合体的*in vitro*和*in vivo*光学成像特性.

主要成果:

合成的配体成功形成了动态惰性和热力学稳定的Ln³⁺复合体.
该Gd³⁺复合体表现出积极的体内MRI特征,具有良好的对比度和快速的清除.
欧3+复合体表现出极好的一光子和两光子吸收,使斑马鱼胚胎的高质量*in vivo*2P显微镜成像和活细胞的*in vitro*成像成为可能.

结论:

一种多用途的DOTA型联体被开发用于基于兰化物的多式成像剂.
由此产生的Gd³⁺和Eu³⁺复合体显示出对先进的*in vivo*MRI和光学成像应用的显著前景.

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