不同的干燥稀释桃子多的生物可访问性和跨甲状腺运输机制中的综合作用
Chongting Guo1,2, Xuan Li1, Jiaxing Hu1
1Key Laboratory of Agricultural Product Processing and Storage, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China.
在50°C的热空气干燥显著提高了稀释桃子多的生物可访问性和吸收. 与冷和自然干燥方法相比,这种干燥方法改善了多的稳定性和运输.
科学领域:
- 食品科学 食品科学 食品科学
- 营养生物化学 营养生物化学
- 药理动力学 药理动力学
背景情况:
- 稀释桃子中的多具有潜在的健康益处,但它们的生物利用性往往是有限的.
- 优化干燥方法对于保护和增强水果衍生生物活性化合物的生物可访问性和代谢运输至关重要.
研究的目的:
- 评估不同干燥方法 (在50°C的热空气干燥[HAD50],冷干燥[FD],自然干燥[ND]) 对稀释桃子多的生物可访问性和Caco-2细胞运输的影响.
- 在模拟消化后识别代谢物,并研究多运输的机制.
主要方法:
- 在体外模拟的胃肠道消化模型.
- 卡科-2细胞单层模型用于评估细胞吸收和体运输.
- 高性能液态染色学 (HPLC) 和液态染色学-质谱学 (LC-MS) 用于多和代谢物识别.
主要成果:
- 与FD和ND相比,HAD50稀释桃子提取物显示出最高的生物可访问性 (91.19%) 和Caco-2细胞中有利的吸收.
- 酸在模拟消化过程中表现出增强的稳定性,已确定26种代谢物.
- 体运输受到P-glycoprotein (P-gp) 介导的外流和有机离子运输多 (OATP) 介导的外流的影响.
结论:
- 在50°C的热空气干燥是提高稀释桃子多的生物可访问性和透性的有效方法.
- 了解运输机制 (P-gp和OATP) 提供了对多生物可用性的见解.
- 这些发现支持HAD50作为一种优越的加工技术,以最大限度地提高稀释桃子多的健康益处.
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