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神经侵入性西尼罗河病毒呈现为亚急性渐进型四重症和无法治疗的疼痛:一个病例报告

Mick B Reedy¹, Mohammad Abdul Azeem¹, Thanujaa Subramaniam¹

¹Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA, wisc.edu.

Case reports in neurological medicine

|January 9, 2026

概括

西尼罗河病毒 (WNV) 可以导致严重的神经侵入性疾病,模仿运动神经元条件. 早期的血清学检测对于诊断WNV感染至关重要,因为尽管得到了支持性护理,但结果可能很差.

科学领域:

神经学神经学
传染性疾病传染性疾病
病毒学病毒学

背景情况:

西尼罗河病毒 (WNV) 是北美蚊子传播的主要疾病.
虽然通常无症状,但很少有百分比的WNV感染进展到具有高发病率和死亡率的神经侵入性疾病.
神经侵入性WNV可以呈现出多样化和严重的神经缺陷.

研究的目的:

报告一种独特的神经侵入性西尼罗病毒感染病例.
为了突出WNV模仿运动神经元疾病所带来的诊断挑战.
强调血清学检测在诊断神经侵入性WNV中的重要性.

主要方法:

一个57岁的男性的病例报告,在10周的病史中出现了渐进式四肢和疼痛.
进行了神经学检查,MRI和电诊断研究.
血清和脑脊液的血清检测 (IgM和IgG) 检测WNV抗体.
尸检检查以确定病理发现.

主要成果:

该患者出现了模仿肌缩性侧面硬化症的症状,包括四肢缩和运动神经元征兆.
磁力共振扫描显示脊髓T2高强度和腹根增强.
电子诊断研究显示了扩散的活体化.
温氏病毒IgM和IgG标位证实了神经侵入性温氏病毒感染.
尸检显示T细胞介导的脑膜炎与运动神经元,脊髓和外围神经的炎症.

结论:

神经侵入性西尼罗病毒可以表现为模仿运动神经元疾病,造成诊断挑战.
及时的血清检测对于准确诊断WNV神经复杂症至关重要.
尽管有支持性护理和免疫疗法,但由于广泛的中枢和外周神经系统参与,结果可能是严重的.

关键词:

尸体解剖尸体解剖是什么意思案例报告案例报告神经传染病是一种神经传染病.神经侵入性西尼罗病毒病毒.神经肌肉的神经肌肉

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