食蛋膜调节肠道微生物群,并减轻小鼠AOM/DSS诱导的结肠炎症
Wenqiang Yin1, Sihui Ma2,3, Maki Igarashi2,4
1Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Bioscience reports
|January 9, 2026
概括
蛋膜 (ESM) 补充剂在与大肠炎相关的结肠直肠癌 (CAC) 鼠标模型中改善了生存率和减少了炎症. 此外,ESM还恢复了肠道微生物群的平衡,显示了作为对抗慢性炎症的饮食策略的潜力.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 持续的肠道炎症和肠道失调是炎症性肠病 (IBD) 进展到结肠炎相关结肠直肠癌 (CAC) 的关键因素.
- 蛋膜 (ESM) 显示出IBD的治疗潜力,但其在炎症驱动的CAC中的有效性尚未得到充分证实.
研究的目的:
- 为了研究饮食ESM补充剂对阿佐西甲/德克斯硫酸 (AOM/DSS) 诱导的CAC小鼠模型的影响.
- 评估ESM对CAC炎症,肠道微生物群和全身器官损伤的影响.
主要方法:
- 在AOM/DSS诱导之前和期间,小鼠接受了对照或ESM补充饮食.
- 分析了结肠炎的严重程度,促炎性标记物,M1巨细胞标记物,肝脏组织学和肠微生物群组成.
主要成果:
- 在接受AOM/DSS治疗的小鼠中,ESM补充剂显著提高了生存率,并减少了结肠炎的严重程度.
- 在ESM下调的促炎细胞因子和M1标志物,减轻肝炎,并保留肝脏结构.
- ESM恢复了肠道微生物群的组成,减少了致病性细菌,丰富了有益的种群,预计可以恢复微生物代谢途径.
结论:
- 在CAC模型中,饮食ESM减轻多器官炎症并恢复微生物平衡.
- 作为一种饮食干预措施,ESM在慢性炎症及其在CAC中的全身影响管理方面显示出潜力.
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