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相关概念视频

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

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In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
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在活跃的狼性炎中,冠状腺厚度.

Letícia Maria Kolachinski Raposo Brandão1, Lucas Parente de Andrade2, Débora Cordeiro do Rosário1

  • 1Division of Rheumatology, Faculdade de Medicina, Hospital Das Clínicas, Universidade de São Paulo, São Paulo, Brazil.

Lupus
|January 9, 2026
PubMed
概括

患有活跃性狼性炎 (LN) 的患者表现出胆道厚度 (CT) 的减少. 这一发现表明,胸膜是LN的亚临床点器官,CT可以帮助非侵入性地监测疾病活动.

关键词:
有活性的狼性炎.胆体 胆体 胆体光学连贯性断层扫描技术

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科学领域:

  • 眼科医生 眼科 眼科
  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 类风湿病学 类风湿病学

背景情况:

  • 狼冠状病与严重的全身性红斑狼 (SLE) 活动和狼性炎 (LN) 有关.
  • 胸膜厚度 (CT) 与球血管干扰或LN活动之间的关系仍在争论中.
  • 这项研究在治疗前对活跃的LN患者进行CT检查.

研究的目的:

  • 在患有活跃狼性炎 (LN) 的患者中评估胆道厚度 (CT).
  • 为了比较活跃的LN患者的CT与健康的对照组.
  • 探索CT作为LN活动的潜在指标.

主要方法:

  • 一项涉及28名活跃LN患者和健康对照者的病例控制横截面研究.
  • 患者符合2019年ACR/EULAR标准的SLE;20名患者的脏活检证实了LN.
  • 使用光谱域光学连贯性断层扫描 (SD-OCT) 测量的胸膜厚度 (CT).

主要成果:

  • 在LN患者和对照组中,年龄和性别分布相似.
  • 与对照组相比,LN患者的中央亚管CT平均值显着较低 (329 ± 69.9 μm与297 ± 41.7 μm相比,p=0.004).
  • 脏参数显示,肌氨酸的中位数为0.80 ± 0.26 mg/dL,蛋白质/肌氨酸比为1.84 ± 1.70 g/g.

结论:

  • 在活跃的LN患者中减少的中央亚叶CT表明,胆管是系统性炎症的亚临床点器官.
  • CT测量是一种有希望的,非侵入性的工具,用于监测LN活动.
  • 需要进一步的纵向研究来确认CT作为LN管理的生物标志物的实用性.