在患有慢性阻塞性肺部疾病的患者中,规定 gabapentinoids 的模式
Mollie Vergara1, Mate Michael Soric1, Olivia King2
1Department of Pharmacy Practice, Northeast Ohio Medical University College of Pharmacy, Rootstown, Ohio, USA.
COPD
|January 9, 2026
概括
在患有慢性阻塞性肺部疾病 (COPD) 的患者中,GABAPENTINOID的处方是常见的,增加了呼吸系统抑郁的风险. 需要更多的提供者教育这些危险的药物相互作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 美国食品和药物管理局 (FDA) 警告说,在患有呼吸道风险因素的患者中,加巴类药物存在严重的呼吸道抑郁风险,包括慢性阻塞性肺部疾病 (COPD).
- gabapentinoid 处方的数量正在增加,这引发了人们对其在 COPD 等脆弱患者群体中的使用的担忧.
研究的目的:
- 评估在被诊断为COPD的患者中 gabapentinoid 处方的患病率和预测因素.
- 在COPD患者中确定与接受 gabapentinoids 风险增加相关的患者特征.
主要方法:
- 分析了2013-2018年 (不包括2017年) 国家门诊医疗调查 (NAMCS) 的数据.
- 检查了1131次未加权的办公室访问,占全国约5360万次.
主要成果:
- 在COPD患者访问的10.8% (1131例中146例) 处方了 gabapentinoids,这意味着每年有超过100万次办公室访问.
- 在COPD患者中使用 gabapentinoid 的预测因素包括同时糖尿病,阿片类药物使用和当前的烟草使用.
结论:
- 在患有COPD的患者中, gabapentinoid的处方是普遍存在的,并且与增加的呼吸系统抑郁风险有关.
- 加强提供者教育对于减轻同时使用COPD和 gabapentinoid的风险至关重要,强调处方时要谨慎.
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