大脑健康风险因素的纵向轨迹通过大脑护理得分和中风,痴呆和抑郁症风险来衡量大脑健康风险因素
Tamara N Kimball1,2,3,4, Reinier W P Tack1,2,3,4, Livia Parodi1,2,3,4
1Brain Care Labs, Mass General Brigham, Boston, MA.
Annals of neurology
|January 9, 2026
概括
改善可修改的风险因素,如通过大脑护理得分 (BCS) 测量的风险因素,与痴呆,中风和抑郁症 (DSD) 的风险降低有关. 这些大脑健康益处是真的,无论遗传倾向或初始风险因素水平如何.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 强有力的证据将可修改的风险因素与与年龄相关的大脑疾病 (痴呆,中风,抑郁症 - DSD) 联系起来.
- 关于这些风险因素变化对现实世界环境中DSD发病率的长期影响的数据有限.
研究的目的:
- 调查可修改的大脑健康风险因素的纵向变化与DDS风险降低之间的关联.
- 评估大脑护理得分 (BCS) 变化对DSD发病率的影响.
主要方法:
- 来自155,469名参与者的英国生物库数据 (2006-2019) 分析,其中包括与GP相关的数据.
- 利用大脑护理得分 (BCS),评估生活方式,身体和社会情绪领域的12个可修改的风险因素.
- 使用线性混合效应模型建模的纵向BCS变化;通过多变量Cox模型评估DSD关联,根据基线BCS和遗传风险进行调整.
主要成果:
- 在12.3年的中位数随访期间,每年BCS增加1点都与发生DSD风险降低4%有关 (HR=0.96,95%CI=0.95-0.97).
- 82.1%的参与者随着时间的推移改善了他们的BCS,年平均增加0.14个点.
- 在BCS的改善与DSD风险的降低有关,无论遗传风险或基线BCS.
结论:
- 可修改风险因子概况的改善与在一个大规模的现实世界队列中,痴呆,中风和抑郁症 (DSD) 的发病率较低显著相关.
- 这些发现强调了改变生活方式对大脑健康的重要性,并为患者与风险因素管理的沟通提供了有价值的信息.
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