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相关概念视频

Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
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Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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基线功能连接预测谁将从神经调节中受益:来自初级渐进性失言症的证据.

Zeyi Wang1,2, Jessica Gallegos3, Donna Tippett3,4,5

  • 1Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA.

Neurorehabilitation and neural repair
|January 9, 2026
PubMed
概括

功能性连接性预测了经过跨直流刺激 (tDCS) 的初级渐进性失言症 (PPA) 患者的语言改善. 在特定的大脑区域的更高的基线连接表明,tDCS对命名和流性有更大的益处.

关键词:
电刺激 (tES) 是一种异质性的异质性下面的前额回路 (inferior frontal gyrus) 是一个较低的前额回路.通过神经调节进行神经调节.精准医学是一门精准医学.预测 预测 预测 预测主要的渐进性失言症.语义流性的语义流性语义检索 语义检索 语义检索跨直流刺激 (tDCS) 是一种语言流 语言流

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 医疗成像医学成像

背景情况:

  • 个性化治疗策略需要了解治疗反应的个体变异性.
  • 在像初级渐进性失言症 (PPA) 这样的异质条件下预测治疗反应是具有挑战性的.
  • 这项研究调查了PPA中对跨直流刺激 (tDCS) 的语言反应的预测因素.

研究的目的:

  • 为了确定个体语言对左下额头 (IFG) 的tDCS反应的预测因素.
  • 为了比较人口,临床,体积和功能连接数据的预测值.
  • 利用一种新的分析方法,专注于治疗效果异质性.

主要方法:

  • 36名PPA患者在3周内接受了活跃或假的tDCS.
  • 人口/临床数据和体积fMRI的预测能力与静止状态功能连接 (FC) 进行了比较.
  • 结果措施包括概括 (语义流) 和主要结果 (书面命名).

主要成果:

  • 功能连接是最强的预测因素,解释了62%的语义流差异和75%的书面命名差异.
  • 人口/临床数据和体积数据预测分别<15%和<23%的差异.
  • 在左IFG内较高的基线FC预测了命名和概括的更大好处;时间区域之间较高的FC预测了概括.

结论:

  • 基线功能连接对于预测PPA中tDCS结果至关重要.
  • 这突显了精准医学在神经调节中的潜力.
  • 这些发现对临床试验有影响,能够准确预测和招募可能的响应者.