基线功能连接预测谁将从神经调节中受益:来自初级渐进性失言症的证据
Zeyi Wang1,2, Jessica Gallegos3, Donna Tippett3,4,5
1Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Neurorehabilitation and neural repair
|January 9, 2026
概括
功能性连接性预测了经过跨直流刺激 (tDCS) 的初级渐进性失言症 (PPA) 患者的语言改善. 在特定的大脑区域的更高的基线连接表明,tDCS对命名和流性有更大的益处.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 个性化治疗策略需要了解治疗反应的个体变异性.
- 在像初级渐进性失言症 (PPA) 这样的异质条件下预测治疗反应是具有挑战性的.
- 这项研究调查了PPA中对跨直流刺激 (tDCS) 的语言反应的预测因素.
研究的目的:
- 为了确定个体语言对左下额头 (IFG) 的tDCS反应的预测因素.
- 为了比较人口,临床,体积和功能连接数据的预测值.
- 利用一种新的分析方法,专注于治疗效果异质性.
主要方法:
- 36名PPA患者在3周内接受了活跃或假的tDCS.
- 人口/临床数据和体积fMRI的预测能力与静止状态功能连接 (FC) 进行了比较.
- 结果措施包括概括 (语义流) 和主要结果 (书面命名).
主要成果:
- 功能连接是最强的预测因素,解释了62%的语义流差异和75%的书面命名差异.
- 人口/临床数据和体积数据预测分别<15%和<23%的差异.
- 在左IFG内较高的基线FC预测了命名和概括的更大好处;时间区域之间较高的FC预测了概括.
结论:
- 基线功能连接对于预测PPA中tDCS结果至关重要.
- 这突显了精准医学在神经调节中的潜力.
- 这些发现对临床试验有影响,能够准确预测和招募可能的响应者.
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