成人发病的亚急性硬化大脑炎呈现出亚急性认知缺陷
Dennis Yeow1,2,3, Nicola McKern3,4, Vincent Oxenham3,4
1Neurodegenerative Service, Prince of Wales Hospital and Neuroscience Research Australia, Sydney, New South Wales, Australia.
Annals of clinical and translational neurology
|January 9, 2026
概括
成年人的亚急性硬化大脑炎 (SSPE) 可以呈现出认知能力下降和前双功能障碍. 早期的神经心理评估可能有助于诊断这种罕见的麻疹并发症.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 病毒性脑炎是一种病毒性脑炎.
背景情况:
- 亚急性硬化大脑炎 (SSPE) 是一种罕见的,进展性神经系统疾病.
- 通常与童年麻疹感染有关,成人发病的SSPE异常罕见.
- 由于不特定的初始症状,早期诊断具有挑战性.
研究的目的:
- 报告一个成人发病的SSPE病例.
- 突出成人发病SSPE的潜在早期诊断指标.
- 强调神经心理测试在诊断SSPE中的实用性.
主要方法:
- 一个41岁的男性患者的病例报告.
- 神经心理学评估详细介绍认知缺陷.
- 磁共振成像 (MRI) 用于大脑缩评估.
- 电脑电图 (EEG) 用于特征波纹.
- 脑脊液 (CSF) 分析用于内抗麻疹IgG合成.
- 诊断基于经过修改的迪肯标准.
主要成果:
- 这名患者表现出渐进的认知缺陷与前端双关节功能障碍.
- 核磁共振扫描显示了轻微的头顶主导的大脑缩.
- 脑电图显示周期性肌细胞冲动与周期性慢波复合体.
- 脑脊液分析证实了内麻疹IgG合成.
- 该患者符合SSPE诊断的修改后的Dyken标准.
结论:
- 成年开始的SSPE是一种罕见但重要的诊断.
- 在神经心理测试中,前端对象认知缺陷可能是成人SSPE的早期迹象.
- 包括EEG,MRI和CSF分析在内的全面诊断工作对于确认SSPE至关重要.
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