评估甲作为治疗耐火性癌症诱导的骨疼痛的治疗方法
Lindsey Dahlquist1, Rebecca Peterson1, Rachel Cook1
1Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, USA.
Journal of pain & palliative care pharmacotherapy
|January 9, 2026
概括
甲有效地减少了癌症引起的骨疼痛 (CIBP) 和需要突破性阿片类药物的需求. 这项研究评估了甲.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 疼痛管理 疼痛管理
背景情况:
- 癌症引起的骨疼痛 (CIBP) 显著影响患者的生活质量.
- 传统的阿片类药物疗法可能不足或与CIBP相关的显著副作用.
- 甲是一种具有独特药理学特性的替代阿片类药物,可能有利于CIBP管理.
研究的目的:
- 评估甲在治疗癌症引起的骨疼痛 (CIBP) 的有效性.
- 在28天的甲治疗后,评估疼痛评分 (数值评分表 - NRS) 的变化.
- 分析甲对突破性阿片类药物需求 (吗啡毫克相当量-MME) 和绩效状态 (ECOG,PPS) 的影响.
主要方法:
- 对27名CIBP患者的回顾性图表审查,这些患者至少接受了28天的甲治疗.
- 疼痛评分 (NRS) 和每日突破性MME在甲开始前后被记录下来.
- 东部合作性瘤学小组 (ECOG) 和息性绩效表 (PPS) 的得分在甲注射前和后被评估.
主要成果:
- 从7 (IQR 5-8) 到4 (IQR 4-5) 的NRS疼痛得分显著降低 (p=0.013).
- 每日突破性MME从90到31显著下降 (p=0.021).
- 没有观察到ECOG或PPS得分的显著变化 (p>0.104).
结论:
- 甲是降低CIBP患者疼痛强度的有效选择.
- 甲显著降低了在CIBP中突破性阿片类药物的需求.
- 在这个患者队列中,甲没有显著改变整体绩效状态 (ECOG,PPS).
更多相关视频
07:23Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
34.0K
05:56Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
1.9K
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
906
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
906
Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
665
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
665
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
