肠道屏障的饮食调节方面的进展:机械,结构和功能洞察力
Jianwei Zang1, Luyao Xiao1, Yibo Shi1
1Sanya Institute of Nanjing Agricultural University, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China.
Comprehensive reviews in food science and food safety
|January 9, 2026
概括
饮食营养素显著影响整个消化道的肠道屏障功能. 了解这些营养物质-肠道-宿主相互作用支持个性化的营养策略,以改善健康.
科学领域:
- 胃肠病学和营养科学 胃肠病学和营养科学
- 肠道屏障的功能是肠道屏障.
- 营养素-肠道-宿主相互作用
背景情况:
- 肠道屏障对宿主健康至关重要,整合了机械,化学,免疫和微生物防御.
- 饮食因素调节屏障完整性,但细肠到结肠的细分特定机制尚未完全理解.
- 本综述侧重于营养素在肠道屏障功能中的作用,以支持精准营养.
研究的目的:
- 审查饮食成分如何影响肠道屏障功能.
- 阐明小肠和结肠中特定营养物的机制.
- 强调基于细分和连续性的营养策略的重要性.
主要方法:
- 关于营养物质-肠道-宿主相互作用的最新进展的文献综述.
- 对饮食中的蛋白质,碳水化合物,脂质,微量营养素和生物活性化合物的临床前和临床证据的分析.
- 专注于影响紧结 (TJ) 表达,上皮细胞修复,炎症和微生物代谢的机制.
主要成果:
- 饮食中的蛋白质 (牛奶,大豆) 调节TJs并支持小肠中的上皮质修复.
- 碳水化合物通过血糖控制和隐蛋白信号传递来调节小肠道屏障.
- 脂质对粘膜炎症和基于和和吸收途径的保护有不同的影响.
- 结肠中的可发酵碳水化合物产生像丁酸盐这样的短链脂肪酸 (SCFA),增强屏障完整性和免疫反应.
- 微量营养素和生物活性化合物 (益生菌,益生菌,后生菌) 维持屏障结构,微生物平衡和免疫信号.
结论:
- 饮食成分对肠道屏障功能产生细分特异性影响.
- 了解整个肠道的营养物-肠-宿主相互作用对于有针对性的营养策略至关重要.
- 这些知识为开发精准营养方法提供了基础,以提高宿主健康.
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