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在阿尔茨海默氏症中视网膜退化5xFAD小鼠食DHA丰富饮食
Mário S Pinho1,2, Husaifa Ahfaz1,2, Sandra Carvalho1,2
1CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.
Cells
|January 9, 2026
概括
从鱼油或微藻类中食多可萨赫萨酸 (DHA) 补充剂可以防止阿尔茨海默病 (AD) 的进展. 摄入的DHA增加了质细胞层密度,并减少了小鼠视网膜中的TAU蛋白,这表明在AD研究中可能存在视网膜生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 营养科学 营养科学
背景情况:
- 阿尔茨海默病 (AD) 涉及认知能力下降和视网膜退化.
- 多可萨赫萨酸 (DHA) 对大脑健康和认知功能至关重要.
- 非鱼类DHA来源为AD预防和治疗提供了潜在的机会.
研究的目的:
- 在小鼠模型中研究各种来源的食DHA补充剂对AD进展的影响.
- 评估视网膜生物标志物,包括神经层厚度,质细胞密度和蛋白质聚合,作为对DHA的反应.
- 评估环保,非鱼类DHA来源作为潜在的AD饮食干预措施.
主要方法:
- 五组5xFAD转基因小鼠被食补充了亚麻油,鱼油,微藻油 (Schizochytrium sp. ) 或商业DHA油 (DHASCO) 6个月.
- 分析了视网膜神经层厚度,质细胞层 (GCL) 密度,以及针对β-粉样质斑块,TAU蛋白和IBA1的免疫组织化学染色.
- 饮食组与接受标准动物饮食的对照组进行了比较.
主要成果:
- 补充DHA并没有显著改变视网膜层厚度.
- 与对照组相比,与DHASCO油养的小鼠 (p < 0.05) 的团细胞层 (GCL) 密度增加 (p < 0.05).
- 与对照群相比,食鱼油的小鼠的TAU蛋白染色明显减少 (p <0.05),TAU阳性细胞数没有变化.
结论:
- 在AD小鼠模型中,食DHA补充剂,特别是来自鱼油和DHASCO,显示出保护视网膜完整性的潜力.
- 增加的GCL密度和减少的TAU病理表明DHA的神经保护作用.
- 视网膜生物标志物可以作为AD研究中认知衰退和整体大脑健康的非侵入性指标.
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