关于β-阿雷斯治疗疼痛的知识图表和新兴趋势:一个文献计量分析 (1997-2025)
Haifang Yu1, Xuehai Ding1, Yiqiang Zhang2
1Department of Anesthesiology, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, China.
Naunyn-Schmiedeberg's archives of pharmacology
|January 9, 2026
概括
这份关于疼痛研究中的β-arrestin的文献分析显示,出版量稳步增加,美国的生产率领先. 关键领域包括偏向性激动性和G蛋白偏向性连接体用于疼痛管理.
科学领域:
- 药理学 药理学是指药理学的学科.
- 疼痛研究 疼痛研究
- 生物医学科学 生物医学科学
背景情况:
- β-arrestins在G蛋白结合受体 (GPCR) 信号传递中发挥着至关重要的作用,影响疼痛通路.
- 了解β-arrestin的参与是开发新型止痛药的关键.
- 阿片类受体是疼痛管理的核心,β-arrestin调节提供治疗潜力.
研究的目的:
- 从1997年到2025年,系统地分析研究成果,核心焦点和β-arrestin在疼痛研究中的进化趋势.
- 澄清发展轨迹,并确定该领域的优先研究领域.
- 为未来的研究方向和治疗策略提供见解.
主要方法:
- 从科学网络,Scopus和PubMed (1997-2025) 的文献图书法分析.
- 包括/排除标准适用于635个选定的物品.
- 分析出版趋势,作者/机构/国家贡献,期刊共同引用和关键字集群与突发检测.
主要成果:
- 观察到关于β-arrestin和疼痛的出版物持续增加.
- 美国是最富有生产力的国家,加利福尼亚大学系统是主要机构.
- "自然"是最被引用的期刊.
- 诸如"mu-阿片类受体"",偏向性激素"和"G蛋白"等关键词显示了显著的趋势.
- 目前的热点包括TRV130 (oliceridine) 和G蛋白偏差配体.
- 研究前沿侧重于药理学机制,偏向性联结体开发和临床应用.
结论:
- 在疼痛研究中,β-arrestin具有重要的治疗潜力.
- 挑战包括阐明β-arrestin2信号差异,量化功能选择性,并澄清不良影响的关联.
- 跨学科的合作对于推进基于β-阿雷斯的疼痛管理策略至关重要.
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