在过度活跃的膀中达里芬素的副作用和中止率:随机对照试验的系统审查和元分析

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Vineesha Veer¹, Felicity Smith¹, Anna Mae Scott^2,3

¹Centre for Urology Research, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, 4226, Australia.

Naunyn-Schmiedeberg's archives of pharmacology

|January 9, 2026

概括

用于过度活动的膀 (OAB) 的达里芬素增加了口腔干燥和便秘等副作用,特别是在较高剂量时. 然而,停药率与安慰剂相似,表明尽管有不良事件,但耐受性良好.

科学领域:

药理学药理学是指药理学的学科.
临床医学临床医学
基于证据的医学基于证据的医学.

背景情况:

过度活跃的膀 (OAB) 影响了大量患者群体.
达里芬素是一种用于治疗OAB的处方口服药物.
了解停药率和不良反应 (AE) 对治疗疗效至关重要.

研究的目的:

系统地审查和元分析OAB患者口服达里芬素的中止率和副作用.
通过使用GRADE方法来评估证据的确定性.
为提供有关达里芬素使用的临床决策提供数据.

主要方法:

随机对照试验 (RCT) 的系统审查和元分析.
在PubMed,Embase和Cochrane CENTRAL中进行的搜索.
使用了偏差风险评估和GRADE; 报告遵循了PRISMA指南.

主要成果:

包括7个RCT,共有2381名参与者.
使用达里芬素时,口腔干燥 (p < 0.0001,中等确定性) 和便秘 (p < 0.0001,高确定性) 的发生率较高,显示了剂量反应.
在达里芬素和安慰剂组之间的总中止率没有显著差异 (RR 0.93,95% CI 0.72-1.20).

结论:

对OAB的达里芬素处方与口腔干燥和便秘的增加有关,与剂量-反应关系有关.
尽管副作用较高,但达里芬素似乎被很好地容忍,与安慰剂相比,停药率相似.
这些发现支持达里芬素的使用,同时强调需要管理相关副作用.

关键词:

乙烯基胆是一种坚持的坚持坚持的坚持膀疾病是一种膀疾病.肌肉性受体的受体是什么泌尿膀的尿液是如何形成的

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