结肠癌的手术前化疗和短期结果 - 全国范围的队列研究
M Delorme1, E Agger2, F Jörgren3
1Department of Surgery, Skåne University Hospital, Lund University, 214 21, Malmö, Sweden. mathilde.delorme@med.lu.se.
International journal of colorectal disease
|January 9, 2026
概括
针对高风险结肠癌的手术前化疗 (preCHT) 在短期内显示出与前期手术相比的安全性. 患有cT4疾病的患者的结局类似,这表明preCHT的可行性.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 临床研究 临床研究
背景情况:
- 高风险结肠癌可能受益于手术前化学疗法 (CHT).
- 基于人口的有限证据存在于短期安全性和预CHT在其指导方针纳入之前的结果.
研究的目的:
- 评估II-III期结肠癌患者手术前化疗 (preCHT) 的短期安全性和结果.
- 在基于人口的队列中,比较preCHT与开端手术的结果.
主要方法:
- 瑞典结肠直肠癌注册 (2007-2017) 的回顾性分析.
- 计划进行预CHT和预先手术的患者的比较.
- 主要结局包括30日和90日死亡率和30日主要发病率 (Clavien-Dindo等级≥3).
- 对cT4疾病和多变量逻辑回归的子组分析.
主要成果:
- 在20185名患者中,1.5%接受了前CHT. 术后死亡率在各组之间是可比的.
- 在CHT前组中观察到更高的整体和手术发病率 (Clavien-Dindo等级≥3).
- 在cT4小组中,短期结果相似;没有发现前CHT与死亡率/重大发病率之间的独立关联.
结论:
- 术前化疗 (preCHT) 在cT4N0-2M0结肠癌中似乎是可行的.
- 在这个小组中,预CHT的短期结果与前期手术相当,尽管疾病更为晚期和进行了广泛的手术.
更多相关视频
06:28E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
8.8K
03:43Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists
Published on: July 11, 2025
615
相关概念视频
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
548
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
548
Cancer Survival Analysis
645
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
645
Endoscopic Procedures II: Colonoscopy
602
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
602
