慢性病中的乳化-线粒体轴:代谢重编程,表观遗传失调和治疗潜力
Yukun Gan1, Junming Zhang1, Xiushuo Fu1
1School of Medicine, Northwest University, Xi'an, 710069, Shaanxi, China.
Molecular and cellular biochemistry
|January 9, 2026
概括
慢性病 (CKD) 涉及纤维化和代谢功能障碍. 向脂肪酸氧化和乳酸代谢可能为病进展提供新的治疗策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在病中代谢途径.
背景情况:
- 慢性病 (CKD) 是一个日益严重的全球健康问题,有效治疗方法有限.
- 脏间歇性纤维化,其特点是细胞外基质沉积过多,是CKD进展的关键病理过程.
- 代谢失调,包括脂肪酸氧化失调 (FAO) 和管状上皮细胞中乳酸代谢的改变,对损伤和纤维化有显著的贡献.
研究的目的:
- 突出维护脂肪酸氧化 (FAO) 对于正常功能的关键作用.
- 探索乳酸代谢在皮质中的重要性及其在病中的损害.
- 作为治疗策略,研究向乳糖化 (一种与炎症和脏病理中的代谢重编程相关的翻译后修饰) 的潜力.
主要方法:
- 对CKD中代谢现有文献的综述.
- 对脂肪酸氧化 (FAO) 在临近管状上皮细胞中的作用的分析.
- 检查乳酸代谢途径和乳酸化对病理学的影响.
主要成果:
- 破坏粮农组织和脂质新陈代谢障碍导致管间纤维化脏损伤.
- 管状上皮细胞中的乳酸代谢受损会导致乳酸积累,炎症和线粒体功能障碍.
- 乳化是一种新陈代谢重编程修改,在脏疾病中的炎症反应和线粒体功能障碍中起作用.
结论:
- 维持FAO对于保持正常功能至关重要.
- 改变乳酸代谢和随后的乳糖化是病病原发生的重要因素.
- 针对乳化过程的干预措施为病中新型治疗策略提供了有希望的途径.
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