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Updated: Jan 13, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

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循环启发的结构优化:设计强大的非核酸逆转录酶抑制剂,提高安全性和选择性.

Yin-Xiang Zhang1, Christophe Pannecouque2, Erik De Clercq2

  • 1Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, State Key Laboratory of Green Chemical Synthesis and Conversion, Fudan University, Shanghai 200433, China.

Journal of medicinal chemistry
|January 9, 2026
PubMed
概括

一种新型的双循环四聚胺衍生物,化合物16a,显示出对HIV-1的强烈活性,包括耐药菌株. 与现有治疗方法相比,这种有前途的候选药物提供了更好的安全性和可溶性.

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