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社区管理:一个有效的模型来降低精神分裂症患者的药物停用率
Hua Ren1, Qin Yang1, Changjiu He1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P.R. China.
PloS one
|January 9, 2026
概括
中国的社区管理显示,精神分裂症患者的药物停用率很低. 改善疾病稳定性,洞察力,管理副作用,并确保定期随访是提高治疗连续性的关键.
科学领域:
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
- 临床药房 临床药房
背景情况:
- 停用药物在精神分裂症中很常见,导致治疗结果不佳.
- 中国的基于社区的管理模式旨在支持患者,但它们在减少停药的有效性需要进一步的证据.
研究的目的:
- 调查在中国社区管理下的精神分裂症患者中药物停用率.
- 在这个人群中确定与药物停用相关的因素.
主要方法:
- 一项横截面研究调查了中国成都1531名精神分裂症患者,使用多阶段采样.
- 通过面对面采访收集的数据包括治疗中止,社会人口统计学,临床特征和服务利用情况.
- 单变量和多变量逻辑回归分析确定了与停药相关的因素.
主要成果:
- 整体药物停用率为4.1%. 药物停用率为4.1%.
- 停止治疗的独立风险因素包括疾病稳定性较弱 (aOR=2.70),缺乏洞察力 (aOR=0.18-0.25),明显的副作用 (aOR=1.98),以及没有定期随访 (aOR=0.22-0.38).
结论:
- 社区管理与精神分裂症患者中断药物的低率有关.
- 优先考虑疾病稳定性,洞察力,副作用管理和社区干预措施的后续遵守,可以改善治疗的连续性.
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