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Updated: Jan 13, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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无意中介的衰变控制了先天免疫感知中的负反循环

Simon Boudreault1, Yahira Rivera-Lopez1, Max B Ferretti1

  • 1Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104.

Proceedings of the National Academy of Sciences of the United States of America
|January 9, 2026
PubMed
概括

无意中介衰变 (NMD) 在病毒感染期间抑制dRNA传感,减少干扰素的产生. 这种NMD抑制作为一个负反循环,控制病毒dRNA水平和塑造先天免疫反应.

关键词:
在RNaseL中使用RNaseL.在 dsRNA 传感器上.没有意义的媒介衰变.

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