拉什转化胃肠道症状评级尺度在1型肌性缩症 (RT-GSRS-DM1) 中
Leandre A la Fontaine1,2, Basil Pap van Veen1,2, Tatiana Hamadeh1,2
1Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
开发一种疾病特异性胃肠道 (GI) 症状测量方法来测量1型肌性缩症 (DM1) 是一个挑战. 广泛使用的GSRS问卷需要进一步细化,以便在DM1中对患者进行准确的评估.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 医疗信息学 医疗信息学
背景情况:
- 肌性衰竭1型 (DM1) 是一种多系统的神经肌肉疾病,具有显著的,但未得到充分评估的胃肠道 (GI) 症状,影响患者的生活质量.
- 目前,对于DM1患者来说,没有疾病特异性GI症状问卷.
- 已建立的胃肠道症状评分表 (GSRS) 缺乏使用DM1的现代临床标准的验证.
研究的目的:
- 用拉什分析评估GSRS对DM1患者的适用性.
- 开发一种疾病特异性,间隔水平的GI症状测量方法来测量DM1.
主要方法:
- 拉什分析被用来评估项目合适性,门排序,差异性项目功能 (DIF),局部依赖性和单维性.
- 模型合适性是通过千平方统计,物品和人体合适度残余以及人与人分离指数 (PSI) 来确定的.
主要成果:
- 从403名DM1患者的初始GSRS数据没有满足Rasch模型的预期.
- 删除了三个项目 (硬便,胃灼热,腹);恶心按年龄划分;由于临床相关性,尽管不适合,便秘仍然存在.
- 最终的模型没有完全满足拉什的要求,尽管可以达到可接受的人分离指数 (0.76).
结论:
- 在DM1中测量胃肠道症状具有重大挑战.
- 这项研究代表了迈向开发更准确,以患者为中心的GI症状测量DM1.0的关键初步步骤.
- 需要进行进一步的研究,以创建一个有效的问卷,准确地反映DM1.患者的经验.
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