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Updated: Jan 13, 2026

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转变的MDC1相互作用和状乳腺癌中功能障碍的DNA修复会对PARP抑制产生敏感性

Joseph L Sottnik1, Madeleine T Shackleford2, Camryn S Nesiba2

  • 1University of Michigan-Ann Arbor Aurora, CO United States.

Cancer research
|January 9, 2026
PubMed
概括

侵袭性叶状乳腺癌 (ILC) 细胞显示由于雌激素受体α (ER) 和MDC1相互作用而导致的DNA修复缺陷. 这种功能障碍使得ILC对PARP抑制剂如talazoparib敏感,提供了一个新的治疗策略.

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