从 Fusarium compactum MM-135 来源的蛋白在老鼠中的亚慢性毒性和原性研究
International journal of toxicology
|January 9, 2026
概括
来自Fusarium compactum MM-135的蛋白是安全的消费. 研究表明,高达20万ppm的剂量对大鼠没有不良影响,支持其作为可持续蛋白质来源的使用.
科学领域:
- 食品科学 食品科学 食品科学
- 毒理学 毒理学 毒理学
- 可持续农业 可持续农业
背景情况:
- 传统的粮食系统面临着诸如土地有限和气候变化等挑战.
- 来自Fusarium compactum (F. compactum) 的菌蛋白MM-135是一种具有良好的营养特征的潜在替代蛋白质来源.
- 以前的研究表明,F. compactum菌蛋白在高达15万ppm的剂量下是安全的.
研究的目的:
- 为了评估F. compactumMM-135菌蛋白的亚慢性毒性.
- 为了评估F. compactum MM-135菌蛋白的致性.
- 为了确定更高剂量的F. compactumMM-135菌蛋白的安全性.
主要方法:
- 一项为期90天的口服毒性研究,对大鼠进行了含有5万,10万或20万ppm菌蛋白的饮食.
- 一项产性研究,从怀孕第6天到第15天,孕妇大鼠被暴露在相同剂量中.
- 确定两项研究的没有观察到不良影响水平 (NOAEL).
主要成果:
- 在90天的毒性研究中,在小鼠中没有观察到高达20万ppm的不良影响.
- 在90天的研究中,NOAEL为200,000ppm (15.26g/kg/day男性,16.20g/kg/day女性).
- 在致性研究中,没有发现对母亲健康或胎儿发育的不良影响,NOAEL为20万ppm (16.53g/kg/天).
结论:
- 来自F. compactum的蛋白MM-135在高达20万ppm的剂量下是安全的.
- 这些发现证实并超过了先前确定的安全值.
- 这些结果支持F. compactum mycoprotein作为安全和可持续的替代蛋白质来源的潜力.
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