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使用美国人口普查分布的结直肠癌查测试的年龄和性别调整的表现

Aasma Shaukat¹, Zhen Meng², Karolina Kutnik²

¹Division of Gastroenterology and Hepatology, NYU Grossman School of Medicine, New York, 10016, NY, USA.

Journal of the National Cancer Institute

|January 9, 2026

概括

对结直肠癌 (CRC) 查的血液测试显示,调整后的绩效指标更接近一般人群. 人口普查调整改善了CRC灵敏度和先进的癌前病变灵敏度,提高了测试的通用性.

科学领域:

在瘤学瘤学.
临床诊断临床诊断临床诊断
生物标志物研究生物标志物研究

背景情况:

结肠直肠癌 (CRC) 查对于早期检测和改善患者的治疗结果至关重要.
基于血液的生物标志物为CRC查提供了一种不那么侵入性的方法.
查测试性能的概括性可以受到研究人口人口统计学的影响.

研究的目的:

评估人口人口统计学对CRC查血液测试的表现的影响.
调整观察到的绩效指标,以反映美国人口普查年龄和性别分布.
评估CRC查血液测试的概括性和临床解释性.

主要方法:

未来的,多中心的观察性研究 (PREEMPT CRC) 以验证CRC查血液测试的性能.
预先规定的分层后分析,将观察到的性能调整为美国人口普查数据.
在人口普查调整之前和之后的绩效指标 (灵敏度,特异性,预测值) 的比较.

主要成果:

预测CRC队列较年轻,女性比例高于美国人口普查人口.
人口普查调整导致名义上更高的CRC敏感性 (81.1%与79.2%) 和高级癌前病变敏感性 (13.7%与12.5%).
晚期结直肠瘤的特异性在调整后名义上较低 (90.4% vs 91.5%),而预测值在各年龄组保持一致.

结论:

对美国人口普查人口统计的分层后调整完善了CRC查血液检测性能的概括性.
血液测试表明在不同年龄组的临床解释性一致.
调整后的性能指标提供了对测试在更广泛的人群中的实用性的更具代表性的观点.

关键词:

血液测试是基于血液的测试.美国人口普查.没有细胞的DNA DNA.临床验证临床验证结肠直肠癌查结肠直肠癌查直接标准化的标准化.液体活检活检液体活检在分层化后进行调整.目标人口的目标人口.

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