感染性内心炎的性别相关差异. 一个回顾性研究在一个大批量手术中心
Valentina Scheggi1, Pier Luigi Stefàno2
1Division of Cardiovascular and Perioperative Medicine, Careggi University Hospital, Cardiothoracovascular Department, Florence, Italy.
Heart & lung : the journal of critical care
|January 9, 2026
概括
传染性内心炎 (IE) 在表现和风险因素方面显示出明显的与性别相关的差异. 虽然女性的死亡率较高,但性别不是独立的预测因素,因此需要针对性别的IE管理策略.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 传染性内心炎 (IE) 呈现出显著的发病率和死亡率,尽管治疗进展.
- 关于IE临床表现,管理和结果的基于性别的差异存在相互矛盾的数据.
研究的目的:
- 为了确定感染性内心炎 (IE) 的临床表现的与性别相关的差异.
- 确定IE患者因任何原因死亡的性别特异性预测因素.
主要方法:
- 追溯分析687个与设备无关的IE病例,这些病例来自一个大量的手术中心 (2013年1月 - 2023年11月).
- 从电子健康记录中收集的数据,包括人口统计,临床,心声和微生物学因素.
- 用于比较基于性别的差异和确定死亡率预测因素的统计方法.
主要成果:
- 女性患者 (34%的队列) 年龄较大,糖尿病和高血压的发病率较高.
- 关IE在女性中更为普遍,而男性则表现出更高的脊髓炎发病率.
- 虽然女性的整体死亡率较高,但在多变量分析中,性别并不能独立预测死亡率.
结论:
- 在IE临床表现和并发症方面存在显著的基于性别的差异.
- 这些发现强调了在IE诊断和治疗中考虑性别的重要性.
- 基于性别的定制方法可能会提高感染性内心炎患者的治疗结果.
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