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在水生物种中对药物污染物的分子相互作用和生物标志物反应

Dibakar Roy¹, Mokhtar Rejili², Wasim Ghafoor³

¹Department of Chemistry and Chemical Biology, Indiana University, Indianapolis, Indiana 47405, USA.

Aquatic toxicology (Amsterdam, Netherlands)

|January 9, 2026

概括

药物,如迪克洛芬雅克和卡巴马泽平,即使在低剂量下,也会损害鱼的肝脏和脏功能. 狄克洛菲纳克构成最大的风险,影响鱼类健康,并为淡水监测提供关键指标.

科学领域:

环境毒理学环境毒理学
水生物质毒理学研究
生物标志物研究的研究.

背景情况:

制药残留物在淡水生态系统中普遍存在.
对药物对鱼类器官系统的次致命作用的理解有限.
需要在暴露和器官层面的损伤之间找到机械联系.

研究的目的:

评估卡巴马泽 (CBZ),迪克洛菲纳克 (DCF) 和素 (FLX) 对Labeo rohita的21天影响.
整合肝脏和脏生物标志物面板与分子对接以获得机械洞察力.
确定用于淡水制药风险评估的实际指标.

主要方法:

在半静态条件下,Labeo rohita暴露于CBZ,DCF和FLX的次致命度.
肝脏标志物 (例如,CYP1A,UGT,GST,抗氧化酶,MDA) 和脏终点 (例如,OATs,COX-2,KIM-1,NAG) 的量化.
选择的蛋白质 (CYP1A,COX-2,SERT,HSP70,Vtg) 与制药化合物的分子对接.

主要成果:

根据严重程度排序的反应:迪克洛芬纳克 (DCF) > 卡巴马泽平 (CBZ) > 素 (FLX).
DCF诱导了显著的生物转化,抑制了抗氧化剂防御,导致氧化损伤和严重的损伤.
CBZ导致了中度的健康影响,而FLX引起了轻微的变化.

结论:

生物标记面板提供了对鱼健康的制药风险的证据.
在测试的药物中,狄克洛菲纳克构成最重要的风险.
该研究提供了监测淡水系统中制药污染的实际指标.

关键词:

细胞染色体P450的使用.内分泌干扰干扰内分泌系统在的药理动力学.氧化应激是一种氧化应激.药物毒性药物毒性药物毒性

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