Th2-M2两极化在腺体缩的发病过程中主要以2型炎症为特征
Zheng Gu1, Zong-Tong Lin2, Zhong-Jie Yang2
1Department of Otolaryngology, West China Second University Hospital, Sichuan University,Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610066, China.; Department of Otolaryngology and Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Child Infection and Immunity, No. 136, Zhong Shan Second Road, Yu Zhong District, Chongqing 400014, China.
Th2-M2极化与过敏性鼻炎 (AR) 的腺体缩 (AH) 有关,可能通过STAT6/SOCS1通路. CHI3L2可以作为AH的这种炎症亚型的生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科耳鼻喉科 儿科耳鼻喉科
背景情况:
- 腺体缩 (AH) 在儿童中很常见,影响发育,但其致病性尚不清楚.
- 这项研究调查了T助手2 (Th2) 和M2巨细胞 (M2) 在AH中的两极分化作用,重点关注2型炎症.
研究的目的:
- 探索Th2-M2两极化在过敏性鼻炎 (AR) 的腺体缩 (AH) 病变发生过程中的参与.
- 确定关键的分子通路和与2型炎症占主导地位的AH相关的潜在生物标志物.
主要方法:
- 在AH/AR患者和对照者的腺体组织中比较了Th细胞子集,转录因子和2型细胞因子 (IL-4,IL-13) .
- 评估M2巨细胞在腺体组织中的分布和数量.
- 利用转录组RNA测序来识别差异表达的基因并进行功能验证.
- 建立了巨细胞和T细胞与IL-4和Dermatophagoides farinae干预的共同培养系统.
主要成果:
- 在AR的AH中,2型和Th17型炎症占主导地位.
- M2巨细胞参与了2型炎症占主导地位的AH的病变发生.
- 转录组分析发现CHI3L2,SOCS1和STAT6是差异表达的基因.
- Th2-M2交叉促进M2通过STAT6/SOCS1途径的两极分化,有助于AH的发病. CHI3L2在2型炎症占主导地位的AH中表达高.
结论:
- Th2-M2极化,可能通过STAT6/SOCS1通路,通过促进M2极化和细胞增殖,有助于2型炎症占主导地位的AH.
- CHI3L2是这种AH亚型中高度表达的基因,也是潜在的生物标志物.
- 需要进一步的研究来证实CHI3L2在AH中的功能作用和治疗潜力.
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