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通过新型共生菌调节肠道微生物群,通过肠-卵巢轴改善老年产母的生产性能和卵巢功能
Jing-Bo Liu1, Song Li2, Guo-Zheng Sun1
1College of Biological and Brewing Engineering, Taishan University, Tai'an City, 271000, China.
Poultry science
|January 9, 2026
概括
一种新型共生菌 (Bacillus amyloliquefaciens + inulin,BAI) 通过调节肠道微生物群,改善了老母的生产性能和卵巢功能. 这种方法改善了肠道健康,减少了氧化应激.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 生殖生物学 生殖生物学
背景情况:
- 由于氧化应激和卵巢功能障碍,老年产母的生产性能下降.
- 肠道微生物群对产母的健康和生产力起着至关重要的作用.
- 准肠道微生物群是一种潜在的策略,可以提高老的表现.
研究的目的:
- 为了研究一种新型共生菌 (Bacillus amyloliquefaciens + inulin,BAI) 对老母的影响.
- 通过多奥米克分析,阐明BAI对生产绩效,肠道健康和卵巢功能作用的潜在机制.
主要方法:
- 在老龄化产母中补充BAI.
- 评估生产性能,肠道形态,免疫状况,卵巢功能和激素水平.
- 多omics分析包括16S rRNA测序,血液代谢学和卵巢转录学.
- 便微生物群移植 (FMT) 实验.
主要成果:
- BAI显著改善了生产表现,肠道健康 (维卢斯高度,屏障基因表达) 和免疫水平.
- BAI通过减少氧化应激,改善卵泡数量,增加生殖激素水平,并升级卵黄前体合成基因来改善卵巢功能.
- BAI调节了肠道微生物群的组成,增加了短链脂肪酸 (SCFA) 生产者,改变了关键代谢物 (SCFA,类固醇生物合成),并抑制了卵巢中的铁和过氧体路径.
- 接受BAI治疗的母的FMT成功地改善了接受母的表现和卵巢功能.
结论:
- 新型协生菌BAI有效地改善了老年产母的生产性能和卵巢功能.
- BAI通过调节肠道微生物群,增强肠道健康和减轻氧化应激来发挥有益作用.
- 用像BAI这样的协生菌来准肠道微生物组是一个有希望的策略,可以缓解与年龄相关的产母的衰退.
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