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在患有多发性硬化症的成年人中,COVID-19的神经序列

Anjali Patel¹, Christine Cherian², Derek Ge³

¹Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA; Cooper Medical School of Rowan University, Camden, NJ 08103, USA.

Multiple sclerosis and related disorders

|January 9, 2026

概括

患有多发性硬化症 (MS) 的患者面临严重的COVID-19结果和恶化的神经精神疾病症状的风险增加. 这凸显了在多发性硬化患者群体中需要仔细管理COVID-19的必要性.

科学领域:

神经学神经学
传染性疾病传染性疾病
免疫学免疫学免疫学

背景情况:

有限的文献表明COVID-19和多发性硬化症 (MS) 中的神经精神症状之间的潜在相互作用.
了解这些相互作用对于在COVID-19大流行期间管理MS患者至关重要.

研究的目的:

调查COVID-19对多发性硬化症 (MS) 患者疾病结果的影响.
评估COVID-19感染后MS患者中急性和慢性神经精神病症状的变化.

主要方法:

一项回顾性队列研究利用了来自国家COVID队列协作 (N3C) 数据库的电子健康记录.
26,963名患有多发性硬化和COVID-19的成年人的倾向性得分与 80,889名患有COVID-19的神经健康成年人的倾向性得分相匹配.
该研究比较了两组之间的一般COVID-19结果和特定急性/慢性神经精神病并发症的风险.

主要成果:

患有多发性硬化症的患者对死亡率,住院和长期COVID诊断的风险更高.
多发性硬化患者患有严重COVID-19和9种急性神经精神疾病并发症的几率增加,包括认知障碍和神经疼痛.
五种与MS相关的慢性神经精神症状,如认知障碍,疲劳和抑郁症,在MS组中也更为普遍.

结论:

患有多发性硬化症的人在COVID-19感染后出现不良结果的风险明显更高.
对于被诊断患有COVID-19的MS患者来说,提高警和量身定制的管理策略至关重要.

关键词:

在 COVID-19 疫情中,电子医疗记录电子医疗记录多发性硬化症是多发性硬化症.神经精神病学是一种神经精神病学.倾向性得分匹配的匹配方法

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