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致死性亚黄素B1暴露会触发蜜蜂 (Apis mellifera) 中肠的多维损伤:从组织形态学,转录学和转基因学中获得的综合证据

Xuanpeng Liu¹, Jilian Li¹, Chuan Ma¹

¹State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100193, China; East China Agri-Tech Center of Chinese Academy of Agricultural Sciences (ECS-CAAS), Kunshan, Jiangsu 215300, China.

Journal of hazardous materials

|January 9, 2026

概括

亚毒素B1 (AFB1) 的次致命暴露严重损害了蜜蜂的中肠,改变了免疫反应和肠道微生物. 这种真菌毒素污染威胁着授粉者健康和生态系统稳定.

科学领域:

* 毒理学毒理学毒理学
* 蜜蜂养殖蜜蜂养殖蜜蜂养殖
* 环境科学环境科学

背景情况:

* Афлатоксин B1 (AFB1) 是来自阿斯伯吉卢菌的致癌性菌毒素,在蜜蜂花粉中越来越多地发现.
* 长期接触AFB1污染的花粉威胁到蜜蜂 (Apis mellifera) 殖民地健康.
* 尽管AFB1对传粉者的毒理影响具有生态意义,但人们对其毒理影响的了解很少.

研究的目的:

* 为了研究亚致命的AFB1暴露对蜜蜂中体的毒理影响.
*使用综合方法分析细胞,分子和微生物的影响.
* 阐明AFB1对授粉者减少的贡献.

主要方法:

* 蜜蜂中肠组织的组织病理学检查.
*转录形状分析以评估基因表达变化.
*元基因组测序以分析肠道微生物群的组成.
*酶活性测定免疫和氧化应激通路.

主要成果:

*严重的中肠表皮损伤,包括核分解和亡.
* 免疫反应和氧化应激通路的显著失调.
* 中肠微生物群的重大变化,减少了多样性和有益的微生物.

结论:

* 亚致命的AFB1暴露会导致蜜蜂多层次的健康恶化.
*研究结果强调了菌毒素对授粉者的细胞,分子和微生物影响.
* 这项研究促进了对AFB1对蜜蜂健康和授粉服务的威胁的理解.

关键词:

我们的肠道微生物群.组织病理学组织病理学免疫反应的免疫反应.菌毒毒素是一种毒素.氧化应激是一种氧化应激.

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