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Updated: May 8, 2026

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在欧洲分裂源中对中子蛋白质结晶学的前景

Esko Oksanen1

  • 1Division of Computational Chemistry, Lund University, Lund, Sweden; European Spallation Source ESS ERIC, Lund, Sweden; LINXS - Institute of Advanced Neutron and X-ray Science, Lund, Sweden.

Structure (London, England : 1993)
|January 9, 2026
PubMed
概括

欧洲裂变源提供先进的中子蛋白结晶学能力. 专门的设施对于充分利用这种高中子流量来进行分子级生物研究至关重要.

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...