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Updated: Jan 13, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Published on: September 18, 2014

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基化导向的细胞质DNA降解控制了cGAS-STING介导的免疫反应对DNA损伤的反应

Lei Li1, Qi Ye1, Jinlu Ma2

  • 1Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China.

Cancer cell
|January 9, 2026
PubMed
概括

通过cGAS-STING信号传递,DNA损伤会触发免疫反应,但癌症可以阻止这种反应. 我们发现USP7调节TREX1,控制DNA分解和免疫激活,为癌症免疫治疗提供了新的点.

关键词:
在SPOP中发生突变.这就是TREX1的特点.细胞质DNA是细胞质DNA.免疫反应的免疫反应.辐射疗法 辐射疗法

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