父亲的种族和种族之间的关联以及一系列出生缺陷在国家病例控制研究中的相关性
Omobola O Oluwafemi1, Laura E Mitchell1, Jenil R Patel2
1Department of Epidemiology, UTHealth Houston School of Public Health, Houston, Texas, USA.
Annals of epidemiology
|January 9, 2026
概括
父亲的种族和族裔与特定的出生缺陷有关,包括异质和胃. 即使考虑到母性因素,这些关联仍然存在,这表明存在复杂的潜在机制.
科学领域:
- 生殖健康 生殖健康
- 遗传学和基因组学 遗传学和基因组学
- 流行病学 流行病学
背景情况:
- 在全球范围内,出生缺陷影响着大量婴儿.
- 了解出生缺陷的风险因素对于预防和干预至关重要.
- 越来越多的人认为,包括种族和族裔在内的父亲因素对出生结果的潜在贡献者.
研究的目的:
- 调查父亲的种族和种族与一系列出生缺陷之间的关联.
- 确定这些协会是否独立于母亲的种族和种族.
主要方法:
- 从国家出生缺陷预防研究 (1997-2011) 的数据分析.
- 包括有出生缺陷的婴儿和对照婴儿.
- 使用无条件后勤回归来评估父亲的种族/种族和32种特定的出生缺陷之间的关联,调整为母亲的因素.
主要成果:
- 发现了父亲的种族/种族与几种出生缺陷之间的关联.
- 亚洲/太平洋岛屿的父亲与6/32缺陷 (例如肺狭窄) 有关.
- 西班牙裔父亲与6/32缺陷 (例如,异质) 有关,非西班牙裔黑人父亲与7/32缺陷 (例如,胃) 有关.
结论:
- 父亲的种族和种族独立地与特定的出生缺陷有关,如异质性,裂唇和脊柱裂.
- 这些发现强调了对生物,环境和社会因素的进一步研究的需要.
- 这些发现的复制是有必要的,以确认观察到的关联.
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