基于年龄的女性在更年期前,期间和更年期后的代谢健康差异
Bong Nguyen1, Melissa Godar2, Barbara Lohse3
1Department of Biomedical and Health Informatics, University of Missouri-Kansas City School of Medicine, Kansas City, MO; Department of Internal Medicine, University of Missouri - Kansas City School of Medicine, Kansas City, MO.
概括
代谢健康和生活方式的行为在更年期的不同阶段有所不同. 绝经前妇女需要早期风险管理,而绝经前和绝经后妇女应该专注于身体活动和血糖控制.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 妇女健康 妇女健康
背景情况:
- 代谢综合征的风险随着年龄和更年期过渡而增加.
- 了解更年期前 (PreM),更年期过渡 (PeriM) 和更年期后 (PostM) 阶段的代谢差异对于有针对性的干预至关重要.
- 更年期阶段作为女性与年龄相关的代谢变化的代理.
研究的目的:
- 在三个绝经阶段 (PreM (<45岁),PeriM (45-55岁) 和PostM (>55岁) 处于代谢综合征风险的妇女中调查代谢差异.
- 识别与更年期每个阶段相关的不同的生活方式行为和代谢特征.
主要方法:
- 718名妇女的队列被分为预M (15%),PeriM (30.4%) 和PostM (54.6%).
- 收集的数据包括人口统计,生活方式因素 (饮食,压力,物质使用),身体活动 (每日步骤),人体指数 (BMI,腰围) 和生物临床标记 (血压,葡萄糖,HbA1c,HDL,甘油三).
- 统计分析使用了千方位,ANOVA和克鲁斯卡尔-瓦利斯测试.
主要成果:
- 在更年期组中观察到生活方式行为和代谢概况的显著差异.
- 与其他组相比,绝经前妇女表现出更多负面的健康行为和代谢特征 (更高的BMI,腰围).
- 绝经后的女性的压力和BMI最低,但他们的静缩血压,HbA1c和HDL水平最高.
结论:
- 针对性,更年期阶段特定的干预措施是必要的,以提高代谢健康和促进更年期过渡期间健康的生活方式.
- 早期的生活方式和代谢风险管理建议在绝经前妇女.
- 在更年期和更年期后的妇女应该优先保持体育活动和血糖控制,以减轻代谢风险.
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