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宫内臭氧 insufflation 在11个不育母马的影响:一个案例系列

R Moroni¹, D Fanelli¹, S Maltinti¹

¹Department of Veterinary Sciences, University of Pisa, Via Livornese (SP-22), San Piero A Grado (PI) 56122, Italy.

Journal of equine veterinary science

|January 9, 2026

概括

宫内臭氧 (O3) 疗法在患有慢性子宫内膜炎的子育马匹中显示出恢复生育能力的前景. 这种治疗导致高受孕率和活小,并改善了子宫内膜组织.

科学领域:

兽医医学兽医医学兽医医学
生殖生物学生殖生物学
马类科学马类科学

背景情况:

马匹持续繁殖诱导的子宫内膜炎会导致慢性子宫炎症和纤维化,影响马匹的生育能力.
对于患有持续性子宫内膜炎的母马来说,常规治疗往往是无效的,导致长期不孕.

研究的目的:

评估子宫内臭氧 (O3) 疗法在恢复子宫下马的生育能力方面的疗效.
评估氧3治疗对子宫内膜组织重塑和巨细胞群的影响.

主要方法:

一系列病例涉及11只对常规疗法的反应不佳的子育马匹.
治疗包括在两个连续的雌性周期内进行子宫内O3气 insufflation,先后进行子宫洗和子宫内膜活检.
马匹被授精,并监测怀孕直到分娩.

主要成果:

在11只马中,有10只 (90.9%) 怀孕,有9只 (81.8%) 生下了活.
治疗后的子宫内膜活检显示CD163+ M2巨细胞的显著增加.
臭氧疗法对子宫内膜组织重塑产生了积极的影响.

结论:

宫内O3疗法可能是慢性子宫内膜炎的子育马匹的生育恢复的可行选择.
观察到的M2巨细胞的增加表明O3影响子宫内膜修复机制.
需要进一步的研究来证实这些发现,并优化O3治疗方案.

关键词:

在子宫内膜炎中,子宫内膜炎.子宫内膜 (Endometrium) 是一个内膜.基因表达基因表达马马的马,就是马马.臭氧臭氧是什么?臭氧臭氧是一种亚生育能力不能生育

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