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Updated: Jan 13, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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通过共结晶增强弱基药物的生物可用性:PBPK对可纳-苏酸的建模

Ana Karolina Santos Goes1, Amira Soliman2, Venkata Krishna Kowthavarpu3

  • 1Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, University of Florida, 6550 Sanger Road, Orlando, FL 32827, USA; Department of Pharmacy, Universidade Estadual do Centro-Oeste (UNICENTRO), Alameda Élio Antonio Dalla Vecchi 838, Guarapuava, PR 85040-167, Brazil.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|January 9, 2026
PubMed
概括

开发了一种基托可纳-苏酸 (KTZ-SA) 协晶,改善了药物的生物可用性. 这种制药性共晶配方克服了pH依赖的溶解,确保在不同患者群体和联合使用的药物中保持一致的KTZ暴露.

关键词:
生物可用性 生物可用性在Cocrystal中使用.结晶化 (Cocrystallization) 是一个过程.凯托可纳醇 (Ketoconazole) 是一种可靠的药物.PBPKK PBPK 的意思是什么意思

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