使用铜离子复合和电喷离子化-双重质谱法,区分CBD和Δ9THC异构体
Alleigh N Couch1, Christopher M Zall2, J Tyler Davidson1
1Department of Forensic Science, Sam Houston State University, Huntsville, TX, USA.
Analytica chimica acta
|January 9, 2026
概括
铜离子复合提供了一种新的方法来区分合法大麻和非法大麻,通过区分Δ9-THC异构体. 这种技术有助于准确地分析大麻素,以符合监管要求.
科学领域:
- 分析化学 分析化学
- 法医科学 法医科学 法医科学
- 生物化学 生物化学
背景情况:
- 2018年农业法案根据Δ9-THC含量将大麻与大麻区分开来,需要精确的分析方法.
- 目前的立法要求对大麻素进行定量分析,由于存在Δ9-THC异构体,这就带来了挑战.
- 在法律和法医应用中,区分大麻 (CBD) 和Δ9-四大麻 (Δ9-THC) 同位体至关重要.
研究的目的:
- 研究铜 (Cu) 离子复合作为一种新的方法,用于区分CBD和Δ9-THC异构体.
- 为了识别由Cu-cannabinoid复合体产生的特征性离子,以区分异构体.
- 评估离子复合在分析现实大麻样品中的适用性.
主要方法:
- 使用了电子喷射电离-并联质谱法 (ESI-MS/MS).
- 铜 (Cu+) 离子被用来与各种大麻素形成复合物.
- 分析全扫描质谱,以确定特征性离子,表明特定的大麻素和同位素.
主要成果:
- 铜离子复合产生了诸如 Δ9-THC,CBD, Δ9-THCA 和 CBDA 等常见大麻素的独特离子.
- 基于独特的质谱特征,D9-THC成功地从D8-THC中分离出来.
- 该方法使用模拟混合物和强化大麻提取物进行了验证,尽管由于离子竞争,真实提取物出现了挑战.
结论:
- 铜离子复合是一种有前途的新方法,用于区分Δ9-THC异构体.
- 这种技术为目前面临大麻测试局限性的分析方法提供了替代方案.
- 精确区分Δ9-THC异构体对于区分合法大麻和非法大麻至关重要.
关键词:
类大麻素 (cannabinoids) 是一种类大麻素.大麻大麻大麻大麻大麻大麻大麻大麻铜离子复合的复杂化电子喷射电离-并联质谱学 (ESI-MS/MS) 是一种碎片化 碎片化异构体的分化差异化更多相关视频
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