相关实验视频

Updated: Jan 13, 2026

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

鸟类菌菌菌感染诱导了巨细胞中的PD-L1过度表达:可能与免疫逃生有关

Hiromu Yano^1,2, Yukio Fujiwara³, Remi Mito⁴

¹Department of Tumor Pathology, Graduate School of Health Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.

Cell death & disease

|January 9, 2026

概括

非结核菌菌 (NTM) 感染很难治疗. 阻止巨细胞上的PD-L1可能通过减少T细胞耗尽来改善对NTM的免疫反应.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
传染性疾病传染性疾病

背景情况:

非结核菌菌 (NTM) 感染带来了重大治疗挑战,原因是治疗耐药性和缺乏向药物.
新出现的证据表明,免疫检查点抑制剂可能为肺NTM感染提供一种新的治疗途径.

研究的目的:

在NTM感染期间调查巨细胞中免疫检查点分子表达.
确定这些分子对受感染病变微环境和细胞免疫的影响.

主要方法:

大量RNA测序和西部斑点分析Mycobacterium avium感染的巨细胞.
用NTM感染的小鼠模型和人体组织进行免疫染,以评估PD-L1,PD-1和T细胞透.

主要成果:

被NTM感染的巨体表现出一种亲炎性表型,PD-L1表达显著增加.
在巨细胞中增加的PD-L1与减少的T细胞透和增加的T细胞耗尽 (PD-1上调) 在感染的病变中相关.
这些变化表明NTM逃避宿主细胞免疫力的机制.

结论:

似乎NTM感染利用PD-L1/PD-1通路来抑制抗菌菌细胞免疫力.
针对巨细胞的PD-L1是一种潜在的治疗策略,可以克服NTM感染中的免疫逃避.

更多相关视频

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Published on: July 3, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

相关概念视频

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...