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Updated: Jan 13, 2026

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RPA 耗尽激活SLFN11,以消除复制应激增加的细胞

Tyler H Stanage1, Shudong Li1, Sandra Segura-Bayona1

  • 1DSB Repair Laboratory, The Francis Crick Institute, London, UK.

Nature cell biology
|January 9, 2026
PubMed
概括

这项研究表明,复制蛋白A (RPA) 耗尽会触发SLFN11激活和癌细胞死亡,特别是当PrimPol等DNA修复途径不足时. 这一发现为癌症化疗耐药性提供了新的见解.

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