在高血压中加速表观遗传年龄:系统性审查和元分析
C Dollin1,2, M Ward2, M Y C Stafford1
1Centre for Genomic Medicine, Manchester, UK.
概括
高血压 (HTN) 与表观遗传衰老加速 (EAA) 相关,这是生物衰老的标志物. 这一系统性审查证实HTN与EAA增加有关,特别是在使用临床测量血压时.
科学领域:
- 基因组学和表观遗传学
- 心血管健康 心血管健康
- 衰老研究研究 衰老研究
背景情况:
- 慢性年龄是高血压 (HTN) 的已知危险因素.
- 生物衰老标志物,如表观遗传衰老加速 (EAA),显示与HTN不一致的关联.
- 了解EAA在HTN发展中的作用对于有针对性的干预至关重要.
研究的目的:
- 系统地审查和元分析EAA,HTN和血压 (BP) 之间的关联.
- 阐明EAA在HTN的发展和进展中的作用.
- 确定涉及HTN-EAA关系的潜在分子通路.
主要方法:
- 对研究DNA甲基化和HTN/BP的研究进行系统审查和元分析.
- 在六个数据库中搜索相关文献.
- 使用 DAVID 和 STRING 探索分子通路的功能性丰富分析.
- 分析包括来自8项研究的16136名参与者,这些研究使用了三个表观遗传时钟算法.
主要成果:
- 165项研究符合4334个初始记录中的纳入标准.
- 在HTN和EAA增加之间发现了显著的关联 (β:0.29,P < 0.0001).
- 临床测量HTN显示了与EAA在三个表观遗传钟 (Horvath,Hannum,PhenoAge) 的积极关联.
- 在使用自我报告的HTN时,这种关联不清楚.
结论:
- 这是首次系统地展示HTN与EAA的联系.
- 临床测量HTN与EAA的相关性比自我报告的HTN更可靠.
- 建议在表观遗传年龄研究中使用临床测量HTN,以准确理解和潜在的治疗点发展.
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