苏维姆西图加化疗治疗白金耐药性复发卵巢癌妇女:SCORES随机,双盲,第三阶段试验
Guangwen Yuan1, Ge Lou2, Jundong Li3
1Department of Gynecology Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Nature cancer
|January 9, 2026
概括
在卵巢癌中,与安慰剂相比,苏维米图加与化疗结合改善了无进展生存 (PFS) 和整体生存 (OS). 这项研究表明suvemcitug.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学 是一个学科.
背景情况:
- 在基于的化疗后,卵巢癌通常会进展.
- 针对血管内皮生长因子 (VEGF) 的抗血管原疗法在癌症治疗中表现有前途.
研究的目的:
- 为了评估suvemcitug的疗效和安全性,一个VEGF抗体,与化学疗法结合,对于妇女有复发性卵巢癌.
- 评估苏维姆西图格对无进展生存 (PFS) 和整体生存 (OS) 的影响.
主要方法:
- 在SCORES研究中,随机选择了421名卵巢癌患者 (在治疗6个月内进展) 接受suvemcitug加化学疗法或安慰剂加化学疗法.
- 参与者每隔2周接受suvemcitug (1.5 mg/kg) 或安慰剂,以及帕克利塔塞尔,托波特坎或PEGylated脂质体 doxorubicin.
- 主要终点是PFS;关键的次要终点是OS. 此外,还评估了安全性和耐受性.
主要成果:
- 随着suvemcitug (5.5个月) 与安慰剂 (2.7个月) 相比,PFS的中位数显著改善 (HR:0.46,P < 0.001).
- 中位 OS 也得到了改善 suvemcitug (15.3 个月) 与安慰剂 (14.0 个月) (HR: 0.77, P = 0.03) 相比.
- 常见的≥3级不良事件包括中性粒细胞和白细胞数量的降低;对于suvemcitug.没有报告5级事件.
结论:
- 将suvemcitug添加到化疗中可以显著改善复发性卵巢癌妇女的PFS和OS.
- 当与标准化疗方案相结合时,suvemcitug显示出可以容忍的安全性.
- 这些发现支持suvemcitug作为抗性卵巢癌的潜在治疗选择.
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