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翅膀 hymenoptera: 在体外和体内敏感化之间的不一致性
Veronica Alix1, Jareatha Abdul Raheem2, Lauren Gabreski3
1From the Allergy and Immunology, Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio - Lackland AFB, Texas.
Allergy and asthma proceedings
|January 9, 2026
概括
鉴于常见的异常,对黄虫毒素过敏的诊断需要进行皮肤和血清学测试. 皮肤检测可能首要在特定的患者群体中进行,以准确诊断过敏.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 诊断测试 诊断测试 诊断测试
- 黄斑虫的毒液过敏 过敏
背景情况:
- 黄虫毒素过敏的诊断依赖于刺痛反应和毒素特异性免疫球蛋白E (IgE) 通过皮肤或血清学测试.
- 之前的研究报告皮肤和血清学测试之间的矛盾,指南强调补充使用.
- 准确的诊断对于启动毒素免疫疗法至关重要.
研究的目的:
- 为了评估皮肤和血清毒素特异性毒素IgE测试之间的不一致性.
- 确定影响这些诊断方法一致性的因素.
- 为临床实践提供有关最佳过敏测试策略的信息.
主要方法:
- 追溯对125名被诊断患有翅膀虫毒液过敏的患者的回顾.
- 纳入标准:过敏学家诊断,处方毒素免疫疗法,以及皮肤和血清检测结果.
- 收集的数据:人口统计,反应严重程度 (穆勒等级) 和毒液测试结果.
主要成果:
- 33名患者符合纳入标准;年龄在7-69岁之间,55%是女性,94%是穆勒等级≥2反应.
- 观察到较低的一致性 (卡帕系数<0.35),总体不一致性为37%.
- 皮肤检测结果比血清学检测结果更为积极,特别是在男性中,成年人在18岁后被刺伤,30岁后被测试,或刺伤后超过5年.
结论:
- 皮肤和血清检测对海门虫毒素过敏经常显示不一致的结果.
- 建议使用这两种测试方式来确认或反驳过敏诊断.
- 皮肤检测可能是某些患者群体首选的初始方法.
相关概念视频
00:42Cross-reactivity
Overview
02:06Allergic Reactions
Overview
01:26Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
01:30Hypersensitivities
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
01:19Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...