内皮激活和压力指数作为严重缺血性中风的关键预后标志物
Rui-Yun Yu1,2, Zhi-Na Liu3, Yue Wang3
1Xinxiang Central Hospital, Xinxiang, China.
European journal of medical research
|January 9, 2026
概括
内皮激活和压力指数 (EASIX) 是严重缺血性中风 (SIS) 的一个有价值的预后生物标志物. 较高的EASIX水平与SIS患者28天死亡风险的增加显著相关.
科学领域:
- 神经学 神经学
- 关键护理医学 关键护理医学
- 生物标志物研究 生物标志物研究
背景情况:
- 严重缺血性中风 (SIS) 的死亡率很高,内皮功能障碍加剧了神经血管损伤.
- 内皮激活和应激指数 (EASIX) 是一种易于使用的生物标志物,在SIS中具有潜在的预后价值.
研究的目的:
- 在SIS患者中调查EASIX水平与28天全因死亡率 (ACM) 之间的关联.
- 为了评估EASIX的预测准确性,与既定的预后得分相比.
主要方法:
- 利用了MIMIC-IV数据库中的数据,根据log2 (EASIX) 值将786名SIS患者分为分层.
- 采用考克斯的比例危险模型,卡普兰-梅尔分析和受限立方线回归 (RCS) 来评估死亡风险.
- 执行了接收器操作特征 (ROC) 曲线分析,以比较EASIX与SOFA和SIRS得分.
主要成果:
- 较高的EASIX水平与更长的住院/ICU住院和增加28天ACM风险有关.
- 每个单位增加的log2 (EASIX) 与17%的死亡风险上升相关;最高的三位数显示风险显著增加.
- RCS回归发现非线性死亡风险增加超过EASIX0.58;EASIX表现出比SOFA/SIRS更高的预测准确性 (AUC=0.765).
结论:
- EASIX 作为一种简单,可访问的生物标志物,用于早期识别高风险的 SIS 患者.
- 升高的EASIX水平与严重缺血性中风患者28天ACM的风险增加密切相关.
相关概念视频
01:30Acute Coronary Syndrome III: Diagnostic Studies
207
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
207
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
531
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
531
01:17Ischemic Heart Disease: Overview
2.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.8K