年轻和年长的C-AYA癌症幸存者中心血管风险因素 接受过人环素治疗:单中心分析
Matthew Dean1, Ben Bane2, OreOluwa Aluko2
1Internal Medicine Residency, Virginia Commonwealth University, Richmond, VA 23298, USA.
Cancers
|January 10, 2026
概括
20岁以下的癌症幸存者 (C-AYA) 接受了人环素治疗,显示出高水平的脂质不良和高血压. 这些年轻的幸存者不太可能接受关键的心血管风险因素治疗.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 儿科 儿科 儿科
背景情况:
- 儿童,青少年和年轻成人 (C-AYA) 癌症幸存者的心脏毒性疗法增加了心血管事件的风险.
- 心血管风险因素 (CVRFs) 在C-AYA幸存者中至关重要,但在20岁以下的人群中未得到充分研究.
- 之前的研究没有专门研究20岁以下的C-AYA的CVRF,也没有将其与较老的C-AYA进行比较.
研究的目的:
- 评估20岁以下的C-AYA中CVRFs,特别是失脂症和高血压的患病率.
- 为了比较年轻 (<20岁) 和年长 (≥20岁) C-AYAs之间的CVRF流行和管理.
- 用ICD代码评估CVRFs的不足诊断,并评估治疗模式.
主要方法:
- 一个单一中心对276名C-AYAA进行了研究,这些AYAA接受了人环素治疗 (2010-2023).
- 纳入标准:诊断时年龄 ≤39岁,治疗后的脂质面板和≥2次门诊血压测量.
- 使用适合年龄的指导方针评估CVRF患病率,并与ICD-9/10代码患病率进行比较;评估了药物使用 (降脂疗法,抗高血压剂).
主要成果:
- 在整体C-AYA队列中观察到高血脂障碍 (52.9%) 和高血压 (56.2%) 的高患病率.
- 20岁以下的C-AYAs表现出显著的脂质不良症 (51.7%) 和高血压 (31.9%).
- 在C-AYAs<20 (12.6%的ICD诊断) 中,CVRFs,特别是脂质失调症的诊断不足. 年轻的幸存者接受的降脂疗法较少 (2.2%对14.9%) 和抗高血压药 (13.8%对31.0%).
结论:
- 抗脂血症和高血压在C-AYA患者中非常普遍,即使在20岁以下,也接受了人环素治疗.
- 较年轻的C-AYA幸存者 (<20岁) 与CVRF相比,与老年幸存者相比,诊断和治疗不足.
- 迫切需要针对年轻癌症幸存者的CVRF进行有针对性的查和管理策略,以预防长期心血管疾病.
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