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Updated: Jan 13, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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Published on: September 28, 2012

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检测DNA损伤和TP53的功能作为调节器的敏感性,以卡利希胺基抗体-药物结合剂为急性白血病

Camryn M Pettenger-Willey1, George S Laszlo1, Margery Gang2

  • 1Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Cancers
|January 10, 2026
PubMed
概括

在急性白血病中对抗体药物合物如gemtuzumab ozogamicin (GO) 和 inotuzumab ozogamicin (InO) 的耐药性与TP53状态有关. 使用小分子抑制剂向DNA损伤途径可能会增强GO/InO的疗效.

关键词:
在CD2222中,我们可以看到CD22.CD3333 CD3333 CD3333 CD3333 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33 CD33这就是CRISPR/Cas9的作用.患有急性白血病的人.卡利希亚米辛是什么意思药物检查屏幕的使用情况.吉姆图祖马布 (gemtuzumab) 是一种奥佐加米的药物.伊诺图祖马布 (inotuzumab) 是一种奥佐加米辛的药物.

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