便和血液相关的结直肠癌生物标志物:系统性审查
Pumelela Hallom1,2, Pragalathan Naidoo1,2, Sibusiso Senzani1
1Department of Medical Microbiology, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Nelson R. Mandela Medical School Campus, Durban 4001, South Africa.
新的DNA甲基化和microRNA生物标志物显示出对非侵入性结直肠癌 (CRC) 查的前景. 多标记面板为早期CRC检测提供了一种具有成本效益的方法,特别是在资源有限的环境中.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 分子诊断学 分子诊断
背景情况:
- 结肠直肠癌 (CRC) 仍然是全球癌症死亡的主要原因.
- 目前的选方法面临成本和可访问性的局限性,特别是在资源较低的地区.
- 开发负担得起的,非侵入性的生物标志物对于改善早期检测和患者生存至关重要.
研究的目的:
- 系统地审查和评估用于结直肠癌 (CRC) 检测的便和血液基生物标志物.
- 评估各种生物标志物的诊断性能 (灵敏度和特异性),包括DNA甲基化和微RNA.
- 确定有前途的生物标志物和面板,以实现成本效益和可扩展的CRC查.
主要方法:
- 在主要的科学数据库 (PubMed,ScienceDirect,Medline,知识网,谷歌学者) 进行了全面的文献搜索.
- 数据提取的重点是研究细节,样本类型,检测方法和诊断准确度指标.
- 对单个生物标志物和多标志物面板报告的敏感性和特异性的系统分析.
主要成果:
- 像SDC2和SHOX2这样的DNA甲基化标记物显示出高灵敏度 (91.35%).
- 多标记面板,包括基因面板和甲基化面板,实现了高诊断准确度 (例如,分别96.6%和90.7%的灵敏度).
- 微RNA面板 (miR-21,miR-92a,miR-223,miR-182) 显示出优异的性能,敏感度>96%和特异性>75%.
结论:
- DNA甲基化和microRNA生物标记物是非侵入性结肠直肠癌 (CRC) 查的非常有前途的候选者.
- 多标志物方法显著提高了诊断准确度.
- 这些先进的生物标志物面板为早期CRC检测提供了潜在的成本效益和可扩展的解决方案,特别有利于资源有限的设置.
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